The main challenge the Hub will address is cybersecurity and industrial safety. The focus will be on software security, data protection and encryption as well as on security of hardware and cyber-physical systems. The Hub will transfer to firms solutions to fight cyberattacks targeted at digital equipment used in electric power generation and delivery, traffic flow management, public health, banking, national security, etc. Taking advantage of the existing expertise in economics and law, the Hub will address the legal and policy interventions that can deter criminal networks from raising, storing, moving, and using funds through cybercrime. Also, it will tackle digital forensics, for collecting digital evidence of criminal activity.

A second challenge is the training and re-skilling of the human resource. Using the expertise in education, the DIH will search for novel education paradigms, making use of augmented reality, adaptable to different environments and worker roles. The Hub will offer solutions that enable the worker to personalise the workplace and increase comfort and performance. With experts in behavioural sciences, the Hub will study human conduct, censorship, online harassment, infringement of privacy, etc.

Other challenges are quality control and integrated additive manufacturing, energy efficiency in manufacturing and reconfigurable manufacturing cells.